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Article

RNAi-mediated inhibition of HIV-1 by targeting partially complementary viral sequences.

Nucleic acids research - 1 Oct 2009

Liu Ying Poi, Gruber Jens, Haasnoot Joost, Konstantinova Pavlina, Berkhout Ben

Abstract excerpt

Potent antiviral RNAi can be induced by intracellular expression of short hairpin RNAs (shRNAs) and artificial microRNAs (miRNAs). Expression of shRNA and miRNA results in target mRNA degradation (perfect base pairing) or translational repression (partial base pairing). Although efficient inhibition can be obtained, error-prone viruses such as human immunodeficiency virus type 1 (HIV-1) can escape from...

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Identifiers

PMID: 19656954
DOI: 10.1093/nar/gkp644
PMCID: PMC2764431

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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