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Article

Production of multicopy shRNA lentiviral vectors for antiviral therapy.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2011

Henry Scot D, Pan Quiwei, van der Laan Luc J W

Abstract excerpt

For effective RNA interference (RNAi)-based therapies against viral infection, particularly highly mutational viruses like HCV and HIV, combinational strategies that target multiple regions within a viral genome are required to prevent resistance. The use of lentiviral vectors for combinatorial RNAi (coRNAi) offers possibilities to deliver multiple short hairpin RNA (shRNA) sequences simultaneously to individual...

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PMID: 21431694
DOI: 10.1007/978-1-61779-037-9_19

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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