Article
Lysyl oxidase (lox) gene deficiency affects osteoblastic phenotype.
Calcified tissue international - 1 Aug 2009
Pischon N, Mäki J M, Weisshaupt P, Heng N, Palamakumbura A H, N'Guessan P, Ding A, Radlanski R, Renz H, Bronckers T A L J J, Myllyharju J, Kielbassa A M, Kleber B M, Bernimoulin J-P, Trackman P C
Abstract excerpt
Lysyl oxidase (LOX) catalyzes cross-linking of elastin and collagen, which is essential for the structural integrity and function of bone tissue. The present study examined the role of Lox gene deficiency for the osteoblast phenotype in primary calvarial osteoblasts from E18.5 Lox knockout (Lox ( -/- )) and wild type (wt) (C57BL/6) mice. Next to Lox gene depletion, mRNA expression of Lox isoforms, LOXL1-4, was...
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