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Article

Bone's dark side: mutated osteoblasts implicated in leukemia.

Cell research - 1 Apr 2014

Schajnovitz Amir, Scadden David T

Abstract excerpt

Bone-lining osteolineage cells were previously implicated as contributors to hematological disorders and malignancies. A recent report in Nature now demonstrates that a specific mutation in mouse collagen-expressing osteoblastic cells leads to MDS and AML with 100% penetrance and is associated with strikingly similar findings in human patients.

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Identifiers

PMID: 24589711
DOI: 10.1038/cr.2014.26
PMCID: PMC3975504

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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