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Article

Osteocytes regulate senescence of bone and bone marrow

28 Oct 2022

Abstract excerpt

The skeletal system contains a series of sophisticated cellular lineages arising from the mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) that determine the homeostasis of bone and bone marrow. Here, we reasoned that osteocyte may exert a function in regulation of these lineage cell specifications and tissue homeostasis. Using a mouse model of conditional deletion of osteocytes by the expression...

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PMID: 36305580
DOI: 10.7554/elife.81480

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