Article
The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism.
The Journal of biological chemistry - 1 Aug 2008
Aqeilan Rami I, Hassan Mohammad Q, de Bruin Alain, Hagan John P, Volinia Stefano, Palumbo Titziana, Hussain Sadiq, Lee Suk-Hee, Gaur Tripti, Stein Gary S, Lian Jane B, Croce Carlo M
Abstract excerpt
The WW domain-containing oxidoreductase (WWOX) gene encodes a tumor suppressor. We have previously shown that targeted ablation of the Wwox gene in mouse increases the incidence of spontaneous and chemically induced tumors. To investigate WWOX function in vivo, we examined Wwox-deficient (Wwox(-/-)) mice for phenotypical abnormalities. Wwox(-/-) mice are significantly reduced in size, die at the age of 2-3 weeks,...
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