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Article

Immature osteoblast lineage cells increase osteoclastogenesis in osteogenesis imperfecta murine.

The American journal of pathology - 1 May 2010

Li Haitao, Jiang Xi, Delaney John, Franceschetti Tiziana, Bilic-Curcic Ines, Kalinovsky Judy, Lorenzo Joseph A, Grcevic Danka, Rowe David W, Kalajzic Ivo

Abstract excerpt

This study addressed the role of impairment of osteoblastic differentiation as a mechanism underlying pathophysiology of the osteogenesis imperfecta (OI). We hypothesized that combination of impaired osteogenic differentiation with increased bone resorption leads to diminished bone mass. By introducing visual markers of distinct stages of osteoblast differentiation, pOBCol3.6GFP (3.6GFP; preosteoblast) and...

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Identifiers

PMID: 20348238
DOI: 10.2353/ajpath.2010.090704
PMCID: PMC2861105

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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