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Article

Sex-Linked Skeletal Phenotype of Lysyl Oxidase Like-1 Mutant Mice.

Calcified tissue international - 1 Feb 2016

Alsofi Loai, Daley Eileen, Hornstra Ian, Morgan Elise F, Mason Zachary D, Acevedo Jesus F, Word R Ann, Gerstenfeld Louis C, Trackman Philip C

Abstract excerpt

Lysyl oxidases are required for collagen and elastin cross-linking and extracellular matrix maturation including in bone. The lysyl oxidase family consists of lysyl oxidase (LOX) and 4 isoforms (LOXL1-4). Here we investigate whether deletion of LOXL1, which has been linked primarily to elastin maturation, leads to skeletal abnormalities. Left femurs (n = 8), L5 vertebrae (n = 8), and tibiae (n = 8) were analyzed...

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Source

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Identifiers

PMID: 26538021
DOI: 10.1007/s00223-015-0076-4
PMCID: PMC8627178

Genes

LOXL1
LOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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