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Article

Independent impairment of osteoblast and osteoclast differentiation in klotho mouse exhibiting low-turnover osteopenia.

The Journal of clinical investigation - 1 Aug 1999

Kawaguchi H, Manabe N, Miyaura C, Chikuda H, Nakamura K, Kuro-o M

Abstract excerpt

We recently identified a new gene, klotho, which is involved in the suppression of multiple aging phenotypes. The mouse homozygous for a disruption of the klotho locus (kl/kl) exhibited multiple pathological conditions resembling human aging. Histomorphometric analysis revealed low-turnover osteo...

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Identifiers

PMID: 10430604
DOI: 10.1172/JCI5705
PMCID: PMC408412

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10430604-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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