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Article

Osteoblast lineage Sod2 deficiency leads to an osteoporosis-like phenotype in mice.

Disease models & mechanisms - 1 May 2022

Schoppa Astrid M, Chen Xiangxu, Ramge Jan-Moritz, Vikman Anna, Fischer Verena, Haffner-Luntzer Melanie, Riegger Jana, Tuckermann Jan, Scharffetter-Kochanek Karin, Ignatius Anita

Abstract excerpt

Osteoporosis is a systemic metabolic skeletal disease characterized by low bone mass and strength associated with fragility fractures. Oxidative stress, which results from elevated intracellular reactive oxygen species (ROS) and arises in the aging organism, is considered one of the critical factors contributing to osteoporosis. Mitochondrial (mt)ROS, as the superoxide anion (O2-) generated during mitochondrial...

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Identifiers

PMID: 35394023
DOI: 10.1242/dmm.049392
PMCID: PMC9118037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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