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Article

DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jul 2011

Abdallah Basem M, Ditzel Nicholas, Mahmood Amer, Isa Adiba, Traustadottir Gunnhildur A, Schilling Arndt F, Ruiz-Hidalgo María-José, Laborda Jorge, Amling Michael, Kassem Moustapha

Abstract excerpt

Delta-like 1/fetal antigen 1 (DLK1/FA-1) is a transmembrane protein belonging to the Notch/Delta family that acts as a membrane-associated or a soluble protein to regulate regeneration of a number of adult tissues. Here we examined the role of DLK1/FA-1 in bone biology using osteoblast-specific Dlk1-overexpressing mice (Col1-Dlk1). Col1-Dlk1 mice displayed growth retardation and significantly reduced total body...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21308776
DOI: 10.1002/jbmr.346

Genes

DLK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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