Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cellular and molecular mechanism of low-turnover osteopenia in the klotho-deficient mouse.

Cellular and molecular life sciences : CMLS - 1 May 2000

Kawaguchi H, Manabe N, Chikuda H, Nakamura K, Kuroo M

Abstract excerpt

The mouse homozygous for a disruption of the klotho locus (KL-/- or klotho mouse) exhibited multiple pathological conditions resembling human aging. We observed osteopenia in KL-/- mice with a low bone turnover, in which the decrease in bone formation exceeded the decrease in bone resorption and resulted in net bone loss. This pathophysiology resembles closely that of senile osteoporosis in humans. Osteoblastic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Bone and Bones
Share to Bone Density

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Diseases, Metabolic

Share to Glucuronidase

Share to Klotho Proteins

Share to Osteoblasts

Share to Osteoclasts

Source

Open in PubMed Open full text

Identifiers

PMID: 10892339
DOI: 10.1007/s000180050037
PMCID: PMC11146784

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cellular and molecular mechanism of low-turnover osteopenia in the klotho-deficient mouse.PMID 10892339Read ↗

Independent impairment of osteoblast and osteoclast differentiation in klotho mouse exhibiting low-turnover osteopenia.Semantic proximity Read ↗

Double mutations in klotho and osteoprotegerin gene loci rescued osteopetrotic phenotype.Semantic proximity Read ↗

Klotho: a fundamental regulator of aging.Semantic proximity Read ↗

The secreted Klotho protein restores phosphate retention and suppresses accelerated aging in Klotho mutant mice.Semantic proximity Read ↗

Retardation in bone resorption after bone marrow ablation in klotho mutant mice.Semantic proximity Read ↗

Klotho and the aging process.Semantic proximity Read ↗

Augmented Wnt Signaling in a Mammalian Model of Accelerated AgingSemantic proximity Read ↗

Vascular calcification and osteoporosis--from clinical observation towards molecular understanding.Semantic proximity Read ↗

Molecular Basis of Klotho: From Gene to Function in AgingSemantic proximity Read ↗

Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice.Semantic proximity Read ↗

Klotho and aging.Semantic proximity Read ↗

DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.