Article
Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infection.
Proceedings of the National Academy of Sciences of the United States of America - 2 Jun 2009
Yeretssian Garabet, Doiron Karine, Shao Wei, Leavitt Blair R, Hayden Michael R, Nicholson Donald W, Saleh Maya
Abstract excerpt
Inflammatory caspases are important effectors of innate immunity. Caspase-12, of the inflammatory caspase subfamily, is expressed in all mammals tested to date, but has acquired deleterious mutation in humans. A single-nucleotide polymorphism introduces a premature stop codon in caspase-12 in the majority of the population. However, in 20% of African descendants, caspase-12 is expressed and sensitizes to...
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