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Article

Caspase-12 dampens the immune response to malaria independently of the inflammasome by targeting NF-kappaB signaling.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2010

Labbé Katherine, Miu Jenny, Yeretssian Garabet, Serghides Lena, Tam Mifong, Finney Constance A, Erdman Laura K, Goulet Marie-Line, Kain Kevin C, Stevenson Mary M, Saleh Maya

Abstract excerpt

Pathogen sensing by the inflammasome activates inflammatory caspases that mediate inflammation and cell death. Caspase-12 antagonizes the inflammasome and NF-κB and is associated with susceptibility to bacterial sepsis. A single-nucleotide polymorphism (T(125)C) in human Casp12 restricts its expression to Africa, Southeast Asia, and South America. Here, we investigated the role of caspase-12 in the control of...

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Identifiers

PMID: 20876354
DOI: 10.4049/jimmunol.1002517

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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