Article
Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis.
Nature - 1 Nov 2019
Fritsch Melanie, Günther Saskia D, Schwarzer Robin, Albert Marie-Christine, Schorn Fabian, Werthenbach J Paul, Schiffmann Lars M, Stair Neil, Stocks Hannah, Seeger Jens M, Lamkanfi Mohamed, Krönke Martin, Pasparakis Manolis, Kashkar Hamid
Abstract excerpt
Caspase-8 is the initiator caspase of extrinsic apoptosis1,2 and inhibits necroptosis mediated by RIPK3 and MLKL. Accordingly, caspase-8 deficiency in mice causes embryonic lethality3, which can be rescued by deletion of either Ripk3 or Mlkl4-6. Here we show that the expression of enzymatically inactive CASP8(C362S) causes embryonic lethality in mice by inducing necroptosis and pyroptosis. Similar to Casp8-/-...
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