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Article

A possible mechanism for maintenance of the deleterious allele of human CASPASE-12.

Medical hypotheses - 1 Nov 2011

Hermel Evan, Klapstein Kevin D

Abstract excerpt

In humans, a functional CASPASE-12 (CASP12) gene has been identified only in persons of African heritage and has been suggested to play a regulatory role in response to bacterial pathogens and in promoting and increased susceptibility to sepsis. The existence of a gene whose effect is deleterious, and which has been the subject of extensive negative selection in the rest of the human population, implies the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 21872999
DOI: 10.1016/j.mehy.2011.07.041

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