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Article

Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms.

Nature - 6 May 2004

Saleh Maya, Vaillancourt John P, Graham Rona K, Huyck Matthew, Srinivasula Srinivasa M, Alnemri Emad S, Steinberg Martin H, Nolan Vikki, Baldwin Clinton T, Hotchkiss Richard S, Buchman Timothy G, Zehnbauer Barbara A, Hayden Michael R, Farrer Lindsay A, Roy Sophie, Nicholson Donald W

Abstract excerpt

Caspases mediate essential key proteolytic events in inflammatory cascades and the apoptotic cell death pathway. Human caspases functionally segregate into two distinct subfamilies: those involved in cytokine maturation (caspase-1, -4 and -5) and those involved in cellular apoptosis (caspase-2, -3, -6, -7, -8, -9 and -10). Although caspase-12 is phylogenetically related to the cytokine maturation caspases, in...

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Identifiers

PMID: 15129283
DOI: 10.1038/nature02451

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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