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Article

Non-canonical caspase-8 activation by cathepsin B drives anti-inflammatory human macrophage polarization

2025-08-26

Abstract excerpt

Anti-inflammatory monocyte-derived macrophages are essential to maintain tissue homeostasis but can also contribute to disease progression, notably in cancer and fibrosis. Deciphering the signaling pathways that govern their generation could therefore unlock new therapeutic opportunities. Here we uncover a previously unrecognized, non-apoptotic function of caspase-8 in driving both monocyte-to-macrophage different...

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Identifiers and source

Literature Corpus work
88a8b912-e75f-5cac-965e-d9f7138758ae
DOI
10.1101/2025.08.22.671722
Open publication

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Non-canonical caspase-8 activation by cathepsin B drives anti-inflammatory human macrophage polarizationDOI 10.1101/2025.08.22.671722
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