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Evolutionary Dynamics of Proinflammatory Caspases in Primates and Rodents

17 Oct 2024

Abstract excerpt

Caspase-1 and related proteases are key players in inflammation and innate immunity. Here, we characterize the evolutionary history of caspase-1 and its close relatives across 19 primates and 21 rodents, focusing on differences that may cause discrepancies between humans and animal studies. While caspase-1 has been retained in all these taxa, other members of the caspase-1 subfamily (caspase-4, caspase-5,...

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PMID: 39431598
DOI: 10.1093/molbev/msae220

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