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Article

Population distribution of the functional caspase-12 allele.

Human mutation - 1 Sept 2006

Kachapati Kritika, O'Brien Thomas R, Bergeron Julie, Zhang Mingdong, Dean Michael

Abstract excerpt

Members of the caspase family can be important for apoptosis or inflammation, but the role of caspase-12 (CASP12 or CSP12) is unclear. Although most humans lack a functional caspase-12, the Csp 12-L variant, previously found only among people of African descent, produces a full-length proenzyme and increases the risk of sepsis. In this study, Csp 12-L allele frequency ranged from 3.6% to 60.7% among populations...

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Identifiers

PMID: 16917906
DOI: 10.1002/humu.9448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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