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Article

Human caspase 12 has acquired deleterious mutations.

Biochemical and biophysical research communications - 3 May 2002

Fischer Heinz, Koenig Ulrich, Eckhart Leopold, Tschachler Erwin

Abstract excerpt

Caspase 12 has been cloned from rodent cells, in which it mediated apoptosis in response to endoplasmic reticulum stress. Based on experiments with murine cells it was suggested that this caspase plays a central role in the pathogenesis of Alzheimer's disease. By alignment of the murine caspase 12 cDNA with the human genome sequence we localized the human caspase 12 gene at a single locus within the caspase 1/ICE...

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Identifiers

PMID: 12054529
DOI: 10.1016/S0006-291X(02)00289-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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