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Article

Activity of caspase-8 determines plasticity between cell death pathways.

Nature - 1 Nov 2019

Newton Kim, Wickliffe Katherine E, Maltzman Allie, Dugger Debra L, Reja Rohit, Zhang Yue, Roose-Girma Merone, Modrusan Zora, Sagolla Meredith S, Webster Joshua D, Dixit Vishva M

Abstract excerpt

Caspase-8 is a protease with both pro-death and pro-survival functions: it mediates apoptosis induced by death receptors such as TNFR11, and suppresses necroptosis mediated by the kinase RIPK3 and the pseudokinase MLKL2-4. Mice that lack caspase-8 display MLKL-dependent embryonic lethality4, as do mice that express catalytically inactive CASP8(C362A)5. Casp8C362A/C362AMlkl-/- mice die during the perinatal...

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PMID: 31723262
DOI: 10.1038/s41586-019-1752-8

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