Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice.

doi:10.1038/nature04656

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Article

Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice.

Nature - 20 Apr 2006

Saleh Maya, Mathison John C, Wolinski Melissa K, Bensinger Steve J, Fitzgerald Patrick, Droin Nathalie, Ulevitch Richard J, Green Douglas R, Nicholson Donald W

Abstract excerpt

Caspases function in both apoptosis and inflammatory cytokine processing and thereby have a role in resistance to sepsis. Here we describe a novel role for a caspase in dampening responses to bacterial infection. We show that in mice, gene-targeted deletion of caspase-12 renders animals resistant to peritonitis and septic shock. The resulting survival advantage was conferred by the ability of the...

Topics

Animals
Caspase 1
Caspase 12
Caspase Inhibitors
Caspases
Catalysis
Cell Line
Disease Susceptibility
Humans
Interferon-gamma
Interleukin-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin-18

Listeria monocytogenes

Mice

Mice, Knockout

Mutation

Peritonitis

Protein Binding

Source

Open in PubMed

Identifiers

PMID: 16625199
DOI: 10.1038/nature04656

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