Article

Evolutionary dynamics of pro-inflammatory caspases in primates and rodents

2024-06-19

Abstract excerpt

Caspase-1 and related proteases are key players in inflammation and innate immunity. Here, we characterize the evolutionary history of caspase-1 and its close relatives across 19 primates and 21 rodents, focusing on differences that may cause discrepancies between humans and animal studies. While caspase-1 has been retained in all these taxa, other members of the caspase-1 subfamily (caspase-4, -5, -11, -12, and C...

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Literature Corpus work: 1559b830-3176-542f-8b35-36dd65cf382e
DOI: 10.1101/2024.06.19.599744

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