Article
A gene-based analysis of variants in the serum/glucocorticoid regulated kinase (SGK) genes with blood pressure responses to sodium intake: the GenSalt Study.
PloS one - 1 Jan 2014
Li Changwei, Yang Xueli, He Jiang, Hixson James E, Gu Dongfeng, Rao Dabeeru C, Shimmin Lawrence C, Huang Jianfeng, Gu Charles C, Chen Jichun, Li Jianxin, Kelly Tanika N
Abstract excerpt
BACKGROUND: Serum and glucocorticoid regulated kinase (SGK) plays a critical role in the regulation of renal sodium transport. We examined the association between SGK genes and salt sensitivity of blood pressure (BP) using single-marker and gene-based association analysis. METHODS: A 7-day low-sodium (51.3 mmol sodium/day) followed by a 7-day high-sodium intervention (307.8 mmol sodium/day) was conducted among...
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