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Article

Therapeutic potential of serum and glucocorticoid inducible kinase inhibition.

Expert opinion on investigational drugs - 1 Jun 2013

Lang Florian, Voelkl Jakob

Abstract excerpt

INTRODUCTION: Expression of serum-and-glucocorticoid-inducible kinase-1 (SGK1) is low in most cells, but dramatically increases under certain pathophysiological conditions, such as glucocorticoid or mineralocorticoid excess, inflammation with TGFβ release, hyperglycemia, cell shrinkage and ischemia. SGK1 is activated by insulin and growth factors via phosphatidylinositide-3-kinase, 3-phosphoinositide-dependent...

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Source

Identifiers

PMID: 23506284
DOI: 10.1517/13543784.2013.778971

Genes

SGK1
CFTR
KCNQ1
STIM1
TRPV4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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