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Article

Calcineurin-NFATc signaling pathway regulates AQP2 expression in response to calcium signals and osmotic stress.

American journal of physiology. Cell physiology - 1 May 2007

Li Song-Zhe, McDill Bradley W, Kovach Paul A, Ding Li, Go William Y, Ho Steffan N, Chen Feng

Abstract excerpt

The aquaporin (AQP)2 channel mediates the reabsorption of water in renal collecting ducts in response to arginine vasopressin (AVP) and hypertonicity. Here we show that AQP2 expression is induced not only by the tonicity-responsive enhancer binding protein (TonEBP)/nuclear factor of activated T cells (NFAT)5-mediated hypertonic stress response but also by the calcium-dependent calcineurin-NFATc pathway. The...

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Source

Identifiers

PMID: 17166937
DOI: 10.1152/ajpcell.00588.2005

Genes

AQP2
NFAT5
AVP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Calcineurin-NFATc signaling pathway regulates AQP2 expression in response to calcium signals and osmotic stress.PMID 17166937Read ↗

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Mutations that reduce its specific DNA binding inhibit high NaCl-induced nuclear localization of the osmoprotective transcription factor NFAT5.Semantic proximity Read ↗

RNA Sequencing Reveals a Role of TonEBP Transcription Factor in Regulation of Pro-inflammatory Genes in Response to Hyperosmolarity in Healthy Nucleus Pulposus CellsSemantic proximity Read ↗

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