Article

HES1 contributes to high salt stress response as an enhancer of NFAT5-DNA binding

2022-10-11

Abstract excerpt

High salt conditions and subsequent hyperosmolarity are injurious cellular stresses but can activate immune signaling. Nuclear factor of activated T-cells 5 (NFAT5) is an essential transcription factor that induces osmoprotective genes such as aldose reductase (AR) and betaine-GABA transporter 1 (BGT1). High salt stress-mediated NFAT5 activation is also reported to accelerate the inflammatory response and autoimmu...

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Literature Corpus work: e8074276-6bd1-5e2c-af5a-30fbcef3672d
DOI: 10.1101/2022.10.10.511678

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