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Article

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1.

Nature - 25 Apr 2013

Wu Chuan, Yosef Nir, Thalhamer Theresa, Zhu Chen, Xiao Sheng, Kishi Yasuhiro, Regev Aviv, Kuchroo Vijay K

Abstract excerpt

TH17 cells (interleukin-17 (IL-17)-producing helper T cells) are highly proinflammatory cells that are critical for clearing extracellular pathogens and for inducing multiple autoimmune diseases. IL-23 has a critical role in stabilizing and reinforcing the TH17 phenotype by increasing expression of IL-23 receptor (IL-23R) and endowing TH17 cells with pathogenic effector functions. However, the precise molecular...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23467085
DOI: 10.1038/nature11984
PMCID: PMC3637879

Genes

SGK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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