Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

G-to-A hypermutation in hepatitis B virus (HBV) and clinical course of patients with chronic HBV infection.

The Journal of infectious diseases - 1 Jun 2009

Noguchi Chiemi, Imamura Michio, Tsuge Masataka, Hiraga Nobuhiko, Mori Nami, Miki Daiki, Kimura Takashi, Takahashi Shoichi, Fujimoto Yoshifumi, Ochi Hidenori, Abe Hiromi, Maekawa Toshiro, Tateno Chise, Yoshizato Katsutoshi, Chayama Kazuaki

Abstract excerpt

BACKGROUND: The apolipoprotein B messenger RNA editing enzyme, catalytic polypeptide-like family of cytidine deaminases induce G-to-A hypermutation in hepatitis B virus (HBV) genomes and play a role in innate antiviral immunity. The clinical relevance of this protein family is unknown. METHODS: We analyzed 33 instances in which 17 patients with chronic HBV infection experienced >2 increases of >100 IU/L in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genome, Viral
Share to Hepatitis B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis B e Antigens

Share to Hepatitis B virus

Share to HIV Infections

Share to Oncogene Proteins, Fusion

Share to RNA, Viral

Share to Transfection

Source

Identifiers

PMID: 19432545
DOI: 10.1086/598951

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

G-to-A hypermutation in hepatitis B virus (HBV) and clinical course of patients with chronic HBV infection.PMID 19432545Read ↗

Dual effect of APOBEC3G on Hepatitis B virus.Semantic proximity Read ↗

Hypermutation of hepatitis B virus genomes by APOBEC3G, APOBEC3C and APOBEC3HSemantic proximity Read ↗

Human cytidine deaminases facilitate hepatitis B virus evolution and link inflammation and hepatocellular carcinoma.Semantic proximity Read ↗

G to A hypermutation of hepatitis B virus.Semantic proximity Read ↗

Massive APOBEC3 editing of hepatitis B viral DNA in cirrhosis.Semantic proximity Read ↗

Hepatitis C virus induces a mutator phenotype: enhanced mutations of immunoglobulin and protooncogenes.Semantic proximity Read ↗

Analysis of hepatitis B virus genotypes and pre-core region variability during interferon treatment of HBe antigen negative chronic hepatitis B.Semantic proximity Read ↗

Naturally Occurring Hepatitis B Virus Genomes Bearing the Hallmarks of Retroviral G → A HypermutationSemantic proximity Read ↗

The inhibition of hepatitis B virus by <scp>APOBEC</scp> cytidine deaminasesSemantic proximity Read ↗

Extensive editing of both hepatitis B virus DNA strands by APOBEC3 cytidine deaminases <i>in vitro</i> and <i>in vivo</i>Semantic proximity Read ↗

Association of human APOBEC3 cytidine deaminases with the generation of hepatitis virus B x antigen mutants and hepatocellular carcinoma.Semantic proximity Read ↗

Full genome ultra-deep pyrosequencing associates G-to-A hypermutation of the hepatitis B virus genome with the natural progression of hepatitis B.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.