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The inhibition of hepatitis B virus by <scp>APOBEC</scp> cytidine deaminases

8 Nov 2013

Abstract excerpt

APOBEC3 (A3) cytidine deaminases are a family of enzymes that have been shown to inhibit the replication of HIV-1 and other retroviruses as part of the innate immune responses to virus infection. They can also hyperedit HBV DNA and inhibit HBV replication. Although A3 proteins are present at low levels in normal liver, A3 gene expression is highly stimulated by both interferon-α and interferon-γ. A3 deaminases...

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PMID: 24304451
DOI: 10.1111/jvh.12192

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