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Article

Massive APOBEC3 editing of hepatitis B viral DNA in cirrhosis.

PLoS pathogens - 27 May 2010

Vartanian Jean-Pierre, Henry Michel, Marchio Agnès, Suspène Rodolphe, Aynaud Marie-Ming, Guétard Denise, Cervantes-Gonzalez Minerva, Battiston Carlo, Mazzaferro Vincenzo, Pineau Pascal, Dejean Anne, Wain-Hobson Simon

Abstract excerpt

DNA viruses, retroviruses and hepadnaviruses, such as hepatitis B virus (HBV), are vulnerable to genetic editing of single stranded DNA by host cell APOBEC3 (A3) cytidine deaminases. At least three A3 genes are up regulated by interferon-alpha in human hepatocytes while ectopic expression of acti...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
Share to APOBEC-3G Deaminase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytidine Deaminase

Share to DNA, Single-Stranded

Share to Gene Expression Regulation, Viral

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Source

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Identifiers

PMID: 20523896
DOI: 10.1371/journal.ppat.1000928
PMCID: PMC2877740

Genes

AICDA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20523896-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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