Article
The ELG1 clamp loader plays a role in sister chromatid cohesion.
PloS one - 1 Jan 2009
Parnas Oren, Zipin-Roitman Adi, Mazor Yuval, Liefshitz Batia, Ben-Aroya Shay, Kupiec Martin
Abstract excerpt
Mutations in the ELG1 gene of yeast lead to genomic instability, manifested in high levels of genetic recombination, chromosome loss, and gross chromosomal rearrangements. Elg1 shows similarity to the large subunit of the Replication Factor C clamp loader, and forms a RFC-like (RLC) complex in conjunction with the 4 small RFC subunits. Two additional RLCs exist in yeast: in one of them the large subunit is Ctf18,...
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