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Article

Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae.

Molecular cell - 1 May 2001

Mayer M L, Gygi S P, Aebersold R, Hieter P

Abstract excerpt

We have identified and characterized an alternative RFC complex RFC(Ctf18p, Ctf8p, Dcc1p) that is required for sister chromatid cohesion and faithful chromosome transmission. Ctf18p, Ctf8p, and Dcc1p interact physically in a complex with Rfc2p, Rfc3p, Rfc4p, and Rfc5p but not with Rfc1p or Rad24p. Deletion of CTF18, CTF8, or DCC1 singly or in combination (ctf18Deltactf8Deltadcc1Delta) leads to sensitivity to...

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Source

Identifiers

PMID: 11389843
DOI: 10.1016/s1097-2765(01)00254-4

Genes

RFC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae.PMID 11389843Read ↗

RFCCtf18 and the Swi1-Swi3 complex function in separate and redundant pathways required for the stabilization of replication forks to facilitate sister chromatid cohesion in Schizosaccharomyces pombe.Semantic proximity Read ↗

A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1.Semantic proximity Read ↗

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Allele-specific interactions between the yeast RFC1 and RFC5 genes suggest a basis for RFC subunit-subunit interactions.Semantic proximity Read ↗

Identification of protein complexes required for efficient sister chromatid cohesion.Semantic proximity Read ↗

The ELG1 clamp loader plays a role in sister chromatid cohesion.Semantic proximity Read ↗

Rfc5, in cooperation with rad24, controls DNA damage checkpoints throughout the cell cycle in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Ddc1-Mec3-Rad17 sliding clamp regulates histone-histone chaperone interactions and DNA replication-coupled nucleosome assembly in budding yeast.Semantic proximity Read ↗

Replication factor C complexes play unique pro- and anti-establishment roles in sister chromatid cohesion.Semantic proximity Read ↗

Functional and physical interaction between Rad24 and Rfc5 in the yeast checkpoint pathways.Semantic proximity Read ↗

The RFC2 gene, encoding the third-largest subunit of the replication factor C complex, is required for an S-phase checkpoint in Saccharomyces cerevisiae.Semantic proximity Read ↗

Elg1 forms an alternative RFC complex important for DNA replication and genome integrity.Semantic proximity Read ↗

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