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Article

A structure-function analysis of the yeast Elg1 protein reveals the importance of PCNA unloading in genome stability maintenance.

Nucleic acids research - 7 Apr 2017

Shemesh Keren, Sebesta Marek, Pacesa Martin, Sau Soumitra, Bronstein Alex, Parnas Oren, Liefshitz Batia, Venclovas Ceslovas, Krejci Lumir, Kupiec Martin

Abstract excerpt

The sliding clamp, PCNA, plays a central role in DNA replication and repair. In the moving replication fork, PCNA is present at the leading strand and at each of the Okazaki fragments that are formed on the lagging strand. PCNA enhances the processivity of the replicative polymerases and provides a landing platform for other proteins and enzymes. The loading of the clamp onto DNA is performed by the Replication...

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Source

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Identifiers

PMID: 28108661
DOI: 10.1093/nar/gkw1348
PMCID: PMC5389545

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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