Article
Increased genome instability and telomere length in the elg1-deficient Saccharomyces cerevisiae mutant are regulated by S-phase checkpoints.
Eukaryotic cell - 1 Dec 2004
Banerjee Soma, Myung Kyungjae
Abstract excerpt
Gross chromosomal rearrangements (GCRs) are frequently observed in cancer cells. Abnormalities in different DNA metabolism including DNA replication, cell cycle checkpoints, chromatin remodeling, telomere maintenance, and DNA recombination and repair cause GCRs in Saccharomyces cerevisiae. Recently, we used genome-wide screening to identify several genes the deletion of which increases GCRs in S. cerevisiae....
Topics
- Base Sequence
- Carrier Proteins
- DNA
- DNA Damage
- DNA Helicases
- DNA Repair
- DNA Replication
- DNA-Binding Proteins
- Gene Deletion
- Genome, Fungal
- Genomic Instability
- Methyl Methanesulfonate
- Molecular Sequence Data
- Mutagens
- Mutation