Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of the repeat-tract instability and mutator phenotypes conferred by a Tn3 insertion in RFC1, the large subunit of the yeast clamp loader.

Genetics - 1 Feb 1999

Xie Y, Counter C, Alani E

Abstract excerpt

The RFC1 gene encodes the large subunit of the yeast clamp loader (RFC) that is a component of eukaryotic DNA polymerase holoenzymes. We identified a mutant allele of RFC1 (rfc1::Tn3) from a large collection of Saccharomyces cerevisiae mutants that were inviable when present in a rad52 null mutat...

Topics

Cell Cycle Proteins
DNA Repair
DNA Replication
DNA Transposable Elements
DNA, Fungal
Mutation
Replication Protein C
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9927446
DOI: 10.1093/genetics/151.2.499
PMCID: PMC1460510

Genes

RFC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9927446-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of the repeat-tract instability and mutator phenotypes conferred by a Tn3 insertion in RFC1, the large subunit of the yeast clamp loader.PMID 9927446Read ↗

New functions of Ctf18-RFC in preserving genome stability outside its role in sister chromatid cohesion.Semantic proximity Read ↗

ELG1, a yeast gene required for genome stability, forms a complex related to replication factor C.Semantic proximity Read ↗

The Ctf18RFC clamp loader is essential for telomere stability in telomerase-negative and mre11 mutant alleles.Semantic proximity Read ↗

The ELG1 clamp loader plays a role in sister chromatid cohesion.Semantic proximity Read ↗

Allele-specific interactions between the yeast RFC1 and RFC5 genes suggest a basis for RFC subunit-subunit interactions.Semantic proximity Read ↗

Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants.Semantic proximity Read ↗

Mutagenic and recombinagenic responses to defective DNA polymerase delta are facilitated by the Rev1 protein in pol3-t mutants of Saccharomyces cerevisiae.Semantic proximity Read ↗

Destabilized PCNA trimers suppress defective Rfc1 proteins in vivo and in vitro.Semantic proximity Read ↗

Rad24 truncation, coupled with altered telomere structure, promotes cdc13-1 suppression in S. cerevisiae.Semantic proximity Read ↗

A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1.Semantic proximity Read ↗

S-phase checkpoint pathways stimulate the mobility of the retrovirus-like transposon Ty1.Semantic proximity Read ↗

A mutant allele of the transcription factor IIH helicase gene, RAD3, promotes loss of heterozygosity in response to a DNA replication defect in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.