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Article

New functions of Ctf18-RFC in preserving genome stability outside its role in sister chromatid cohesion.

PLoS genetics - 10 Feb 2011

Gellon Lionel, Razidlo David F, Gleeson Olive, Verra Lauren, Schulz Danae, Lahue Robert S, Freudenreich Catherine H

Abstract excerpt

Expansion of DNA trinucleotide repeats causes at least 15 hereditary neurological diseases, and these repeats also undergo contraction and fragility. Current models to explain this genetic instability invoke erroneous DNA repair or aberrant replication. Here we show that CAG/CTG tracts are stabilized in Saccharomyces cerevisiae by the alternative clamp loader/unloader Ctf18-Dcc1-Ctf8-RFC complex (Ctf18-RFC)....

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Identifiers

PMID: 21347277
DOI: 10.1371/journal.pgen.1001298
PMCID: PMC3037408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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New functions of Ctf18-RFC in preserving genome stability outside its role in sister chromatid cohesion.PMID 21347277Read ↗

Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae.Semantic proximity Read ↗

Expanded CAG/CTG repeat DNA induces a checkpoint response that impacts cell proliferation in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Ctf18RFC clamp loader is essential for telomere stability in telomerase-negative and mre11 mutant alleles.Semantic proximity Read ↗

A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1.Semantic proximity Read ↗

The ELG1 clamp loader plays a role in sister chromatid cohesion.Semantic proximity Read ↗

Characterization of the repeat-tract instability and mutator phenotypes conferred by a Tn3 insertion in RFC1, the large subunit of the yeast clamp loader.Semantic proximity Read ↗

ELG1, a yeast gene required for genome stability, forms a complex related to replication factor C.Semantic proximity Read ↗

Postreplication repair inhibits CAG.CTG repeat expansions in Saccharomyces cerevisiae.Semantic proximity Read ↗

Identification of protein complexes required for efficient sister chromatid cohesion.Semantic proximity Read ↗

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Mutations in yeast replication proteins that increase CAG/CTG expansions also increase repeat fragility.Semantic proximity Read ↗

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