Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GPX1 Pro(198)Leu polymorphism, erythrocyte GPX activity, interaction with alcohol consumption and smoking, and risk of colorectal cancer.

Mutation research - 12 May 2009

Hansen Rikke Dalgaard, Krath Britta Naimi, Frederiksen Kirsten, Tjønneland Anne, Overvad Kim, Roswall Nina, Loft Steffen, Dragsted Lars Ove, Vogel Ulla, Raaschou-Nielsen Ole

Abstract excerpt

GPX1 encoding the enzyme glutathione peroxidase 1 (GPX1) and hOGG1 encoding the 8-oxoguanine glycosylase 1 (OGG1) may counteract oxidative stress and resulting DNA damage associated with lifestyle-related exposures. We examined whether the polymorphisms GPX1 Pro(198)Leu and OGG1 Ser(326)Cys or low erythrocyte GPX enzyme activity in pre-diagnostic blood samples are associated with colorectal cancer risk, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Drinking
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Glycosylases

Share to DNA, Neoplasm

Share to Erythrocytes

Share to Glutathione Peroxidase

Share to Glutathione Peroxidase GPX1

Share to Smoking

Source

Identifiers

PMID: 19428376
DOI: 10.1016/j.mrfmmm.2009.01.009

Genes

GPX1
OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GPX1 Pro(198)Leu polymorphism, erythrocyte GPX activity, interaction with alcohol consumption and smoking, and risk of colorectal cancer.PMID 19428376Read ↗

Associations between GPX1 Pro198Leu polymorphism, erythrocyte GPX activity, alcohol consumption and breast cancer risk in a prospective cohort study.Semantic proximity Read ↗

GPX1 gene Pro200Leu polymorphism, erythrocyte GPX activity, and cancer risk.Semantic proximity Read ↗

Association between GPx1 Pro198Leu polymorphism, GPx1 activity and plasma selenium concentration in humans.Semantic proximity Read ↗

Association between GPX1 Pro189Leu polymorphism and the occurrence of bladder cancer in Morocco.Semantic proximity Read ↗

GPx-1 polymorphism (rs1050450) contributes to tumor susceptibility: evidence from meta-analysis.Semantic proximity Read ↗

GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer.Semantic proximity Read ↗

Association between glutathione peroxidase 1 codon 198 variant and the occurrence of breast cancer in Rwanda.Semantic proximity Read ↗

GPX1 Pro198Leu polymorphism and breast cancer risk: a meta-analysis.Semantic proximity Read ↗

Association of GPX1 polymorphism, GPX activity and prostate cancer risk.Semantic proximity Read ↗

Associations between glutathione peroxidase-1 Pro198Leu polymorphism, selenium status, and DNA damage levels in obese women after consumption of Brazil nuts.Semantic proximity Read ↗

Impact of the Ser326Cys polymorphism of the OGG1 gene on the level of oxidative DNA damage in patients with colorectal cancer.Semantic proximity Read ↗

Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQO1, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.