Association between GPx1 Pro198Leu polymorphism, GPx1 activity and plasma selenium concentration in humans.

doi:10.1007/s00394-009-0023-0

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Association between GPx1 Pro198Leu polymorphism, GPx1 activity and plasma selenium concentration in humans.

European journal of nutrition - 1 Sept 2009

Jablonska E, Gromadzinska J, Reszka E, Wasowicz W, Sobala W, Szeszenia-Dabrowska N, Boffetta P

Abstract excerpt

BACKGROUND: Glutathione peroxidase 1 (GPx1) is an antioxidant selenoenzyme that protects the cells against reactive oxygen species. Its activity depends on the concentration of selenium (Se) which is present in the active centre of the enzyme. The genetic polymorphism of GPx1 encoding gene (GPx1) associated with the proline (Pro) to leucine (Leu) change at codon 198 is supposed to be functional. An in vitro study...

Topics

Aged
Aging
Alleles
Biomarkers
Codon
Erythrocytes
Female
Genotype
Glutathione Peroxidase
Humans
Linear Models
Male
Middle Aged
Poland
Polymorphism, Genetic
Research Design
Selenium
Sex Factors

Source

Open in PubMed

Identifiers

PMID: 19415410
DOI: 10.1007/s00394-009-0023-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics