Article
Association of GPX1 polymorphism, GPX activity and prostate cancer risk.
Human & experimental toxicology - 1 Jan 2012
Erdem O, Eken A, Akay C, Arsova-Sarafinovska Z, Matevska N, Suturkova L, Erten K, Özgök Y, Dimovski A, Sayal A, Aydin Ahmet
Abstract excerpt
Prostate cancer is the second most common cancer in men worldwide. Although the aetiology of this disease remains largely unclear, several lines of evidence suggest that oxidative stress plays a role in prostate carcinogenesis. The antioxidant enzyme glutathione peroxidase 1 (GPX1) is part of the enzymatic antioxidant defence, preventing oxidative damage to DNA, proteins and lipids by detoxifying hydrogen and...
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