Article
Associations between glutathione peroxidase-1 Pro198Leu polymorphism, selenium status, and DNA damage levels in obese women after consumption of Brazil nuts.
Nutrition (Burbank, Los Angeles County, Calif.) - 1 Sept 2011
Cominetti Cristiane, de Bortoli Maritsa Carla, Purgatto Eduardo, Ong Thomas Prates, Moreno Fernando Salvador, Garrido Arthur Belarmino, Cozzolino Silvia Maria Franciscato
Abstract excerpt
OBJECTIVE: Alterations in selenium (Se) status may result in suboptimal amounts of selenoproteins, which have been associated with increased oxidative stress levels. The Pro198Leu polymorphism at the glutathione peroxidase-1 (GPx1) gene is supposed to be functional. The response of Se status, GPx activity, and levels of DNA damage to a Se supplementation trial between the genotypes related to that polymorphism...
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