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Article

Association between sigma-1 receptor gene polymorphism and prefrontal hemodynamic response induced by cognitive activation in schizophrenia.

Progress in neuro-psychopharmacology & biological psychiatry - 30 Apr 2009

Takizawa Ryu, Hashimoto Kenji, Tochigi Mamoru, Kawakubo Yuki, Marumo Kohei, Sasaki Tsukasa, Fukuda Masato, Kasai Kiyoto

Abstract excerpt

The molecular biological role of the sigma-1 receptor (Sig-1R) has attracted much attention. Evidence suggests that the Sig-1R engaged in modulating NMDA and dopamine receptors is involved in the pathophysiology of schizophrenia and the mechanism of psychotropic drug efficacy. However, whether the Sig-1R genotype affects brain function in schizophrenia in vivo remains unknown. We investigated the association...

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Identifiers

PMID: 19439245
DOI: 10.1016/j.pnpbp.2009.01.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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