Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Catechol-O-methyltransferase val108/158met genotype predicts working memory response to antipsychotic medications.

Biological psychiatry - 1 Nov 2004

Weickert Thomas W, Goldberg Terry E, Mishara Aaron, Apud Jose A, Kolachana Bhaskar S, Egan Michael F, Weinberger Daniel R

Abstract excerpt

BACKGROUND: The gene encoding catechol-O-methyltransferase (COMT), an enzyme that regulates prefrontal cortex dopamine, contains a common functional polymorphism (val(108/158)met) that influences prefrontal cortex function in an allelic dose-dependent manner. A recent study reported that the COMT...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antipsychotic Agents
Share to Catechol O-Methyltransferase
Share to Double-Blind Method

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Memory, Short-Term

Share to Mental Status Schedule

Share to Methionine

Share to Neuropsychological Tests

Share to Valine

Source

Identifiers

PMID: 15522252
DOI: 10.1016/j.biopsych.2004.08.012

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15522252-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Catechol-O-methyltransferase val108/158met genotype predicts working memory response to antipsychotic medications.PMID 15522252Read ↗

Catechol-O-methyltransferase polymorphisms and some implications for cognitive therapeutics.Semantic proximity Read ↗

COMT val108/158met genotype, cognitive function, and cognitive improvement with clozapine in schizophrenia.Semantic proximity Read ↗

Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia.Semantic proximity Read ↗

Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia.Semantic proximity Read ↗

Catechol O-methyltransferase variants and cognitive performance in schizophrenia and bipolar disorder versus controls.Semantic proximity Read ↗

MTHFR 677C --> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val --> Met.Semantic proximity Read ↗

COMT (Val(158/108)Met) genotype moderates the impact of antipsychotic medication on verbal IQ in twins with schizophrenia.Semantic proximity Read ↗

Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia.Semantic proximity Read ↗

Association Between the COMT Val158Met Polymorphism and Antipsychotic Efficacy in Schizophrenia: An Updated Meta-Analysis.Semantic proximity Read ↗

Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls.Semantic proximity Read ↗

Meta-analysis of the cognitive effects of the catechol-O-methyltransferase gene Val158/108Met polymorphism.Semantic proximity Read ↗

Catechol-O-methyl transferase and schizophrenia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.