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Article

Impact of catechol-O-methyltransferase on prefrontal brain functioning in schizophrenia spectrum disorders.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2007

Ehlis Ann-Christine, Reif Andreas, Herrmann Martin J, Lesch Klaus-Peter, Fallgatter Andreas J

Abstract excerpt

The enzyme catechol-O-methyltransferase (COMT) has attracted increasing interest regarding a genetic disposition towards schizophrenias and as a modulator of prefrontal brain function. A common SNP in the COMT gene causes a Val to Met transition at AA158/AA108 (Val158Met), resulting in reduced COMT activity in Met allele carriers. An impact of COMT genotype on cognition has been well established; however, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16823382
DOI: 10.1038/sj.npp.1301151

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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