Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation.

Archives of general psychiatry - 1 Dec 2006

Drabant Emily M, Hariri Ahmad R, Meyer-Lindenberg Andreas, Munoz Karen E, Mattay Venkata S, Kolachana Bhaskar S, Egan Michael F, Weinberger Daniel R

Abstract excerpt

CONTEXT: Catechol O-methyltransferase (COMT), the major enzyme determining cortical dopamine flux, has a common functional polymorphism (val(158)met) that affects prefrontal function and working memory capacity and has also been associated with anxiety and emotional dysregulation. OBJECTIVES: To examine COMT val(158)met effects on corticolimbic circuitry reactivity and functional connectivity during processing of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Affect
Share to Affective Symptoms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Amygdala

Share to Arousal

Share to Facial Expression

Share to Limbic System

Share to Temperament

Share to Visual Perception

Source

Identifiers

PMID: 17146014
DOI: 10.1001/archpsyc.63.12.1396

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation.PMID 17146014Read ↗

Aversive stimuli lead to differential amygdala activation and connectivity patterns depending on catechol-O-methyltransferase Val158Met genotype.Semantic proximity Read ↗

Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex.Semantic proximity Read ↗

Influence of the catechol-O-methyltransferase val158met genotype on amygdala and prefrontal cortex emotional processing in panic disorder.Semantic proximity Read ↗

The effects of catechol O-methyltransferase genotype on brain activation elicited by affective stimuli and cognitive tasks.Semantic proximity Read ↗

Catechol-O-methyltransferase gene variation: impact on amygdala response to aversive stimuli.Semantic proximity Read ↗

COMT Val(108/158)Met polymorphism effects on emotional brain function and negativity bias.Semantic proximity Read ↗

Catechol-O-methyltransferase Val(108/158)Met polymorphism affects fronto-limbic connectivity during emotional processing in bipolar disorderSemantic proximity Read ↗

The effects of gender and catechol O-methyltransferase (COMT) Val108/158Met polymorphism on emotion regulation in velo-cardio-facial syndrome (22q11.2 deletion syndrome): An fMRI study.Semantic proximity Read ↗

Neural substrates of pleiotropic action of genetic variation in COMT: a meta-analysis.Semantic proximity Read ↗

Gene-gene effects on central processing of aversive stimuli.Semantic proximity Read ↗

Catechol-O-methyltransferase (COMT) influences the connectivity of the prefrontal cortex at rest.Semantic proximity Read ↗

Interaction between catechol-O-methyltransferase (COMT) Val158Met genotype and genetic vulnerability to schizophrenia during explicit processing of aversive facial stimuli.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.