Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation.

doi:10.1001/archpsyc.63.12.1396

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Article

Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation.

Archives of general psychiatry - 1 Dec 2006

Drabant Emily M, Hariri Ahmad R, Meyer-Lindenberg Andreas, Munoz Karen E, Mattay Venkata S, Kolachana Bhaskar S, Egan Michael F, Weinberger Daniel R

Abstract excerpt

CONTEXT: Catechol O-methyltransferase (COMT), the major enzyme determining cortical dopamine flux, has a common functional polymorphism (val(158)met) that affects prefrontal function and working memory capacity and has also been associated with anxiety and emotional dysregulation. OBJECTIVES: To examine COMT val(158)met effects on corticolimbic circuitry reactivity and functional connectivity during processing of...

Topics

Adult
Affect
Affective Symptoms
Amygdala
Arousal
Brain Mapping
Catechol O-Methyltransferase
Exploratory Behavior
Facial Expression
Female
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Limbic System

Magnetic Resonance Imaging

Male

Methionine

Neural Pathways

Oxygen

Source

Open in PubMed

Identifiers

PMID: 17146014
DOI: 10.1001/archpsyc.63.12.1396

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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