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Article

Neural substrates of pleiotropic action of genetic variation in COMT: a meta-analysis.

Molecular psychiatry - 1 Sept 2010

Mier D, Kirsch P, Meyer-Lindenberg A

Abstract excerpt

Genetic variation in catechol-O-methyltransferase (COMT), encoding an enzyme critical for prefrontal dopamine flux, has been studied extensively using both behavioral and neuroimaging methods. In behavior, pleiotropic action of a functional Val(158)Met (rs4680) polymorphism on executive cognition and emotional stability has been described and proposed to be of evolutionary significance (the 'warrior/worrier'...

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Source

Identifiers

PMID: 19417742
DOI: 10.1038/mp.2009.36

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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