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Article

The role of COMT gene variants in depression: Bridging neuropsychological, behavioral and clinical phenotypes.

Neuroscience and biobehavioral reviews - 1 Sept 2013

Antypa Niki, Drago Antonio, Serretti Alessandro

Abstract excerpt

Depression is a common and disabling psychiatric disorder with a complex etiology, which includes predisposing risk genes and environmental stressors. Variation in the Catechol-O-Methyltransferase (COMT) gene, the Val158Met polymorphism in particular, has been extensively investigated in relation to clinical phenotypes of depression and, in parallel, neurocognitive processes. In this review, we bridge evidence...

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Source

Identifiers

PMID: 23792050
DOI: 10.1016/j.neubiorev.2013.06.006

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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