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Article

Warriors versus worriers: the role of COMT gene variants.

CNS spectrums - 1 Oct 2006

Stein Dan J, Newman Timothy K, Savitz Jonathan, Ramesar Rajkumar

Abstract excerpt

Behavioral phenotypes are generally complex, reflecting the action of multiple different genes. Nevertheless, there is growing evidence that key gene variants can alter activity within specific neuronal circuits and, therefore, influence particular cognitive-affective phenomena. One example is the catechol-O-methyltransferase (COMT) gene, which has a common variant at codon 158. Those with valine (Val158) alleles...

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Source

Identifiers

PMID: 17008817
DOI: 10.1017/s1092852900014863

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Warriors versus worriers: the role of COMT gene variants.PMID 17008817Read ↗

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Effects of COMT polymorphisms on brain function and behavior in health and disease.Semantic proximity Read ↗

Catechol-O-methyltransferase polymorphisms and some implications for cognitive therapeutics.Semantic proximity Read ↗

The role of COMT gene variants in depression: Bridging neuropsychological, behavioral and clinical phenotypes.Semantic proximity Read ↗

COMT Val158Met Genotype and Individual Differences in Executive Function in Healthy Adults.Semantic proximity Read ↗

The effects of catechol O-methyltransferase genotype on brain activation elicited by affective stimuli and cognitive tasks.Semantic proximity Read ↗

The "Warrior" COMT Val/Met Genotype Occurs in Greater Frequencies in Mixed Martial Arts Fighters Relative to Controls.Semantic proximity Read ↗

COMT Val158Met Genotype Determines the Direction of Cognitive Effects Produced by Catechol-O-Methyltransferase InhibitionSemantic proximity Read ↗

Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex.Semantic proximity Read ↗

Effect of catechol-O-methyltransferase val158met genotype on attentional control.Semantic proximity Read ↗

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