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Article

Impact of complex genetic variation in COMT on human brain function.

Molecular psychiatry - 1 Sept 2006

Meyer-Lindenberg A, Nichols T, Callicott J H, Ding J, Kolachana B, Buckholtz J, Mattay V S, Egan M, Weinberger D R

Abstract excerpt

Catechol-O-methyltransferase (COMT) has been shown to be critical for prefrontal dopamine flux, prefrontal cortex-dependent cognition and activation. Several potentially functional variants in the gene have been identified, but considerable controversy exists regarding the contribution of individual alleles and haplotypes to risk for schizophrenia, partly because clinical phenotypes are ill-defined and...

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Source

Identifiers

PMID: 16786032
DOI: 10.1038/sj.mp.4001860

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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